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Skin and hair

Melanotan II

Drug that never made it to the market

  • FormulaC50H69N15O9
  • Molecular weight1024.2 g/mol
  • CAS number121062-08-6
  • PubMed results195

Reference sheet 25 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Identification

Field of researchSkin and hair
PubChem namemelanotan-II
FormulaC50H69N15O9
Molecular weight1024.2 g/mol
CAS number121062-08-6
Also known asUPF5CJ93X7, RefChem:925444, MT-II, Melanotan (MT)-II, Melatonan, Melanotan II acetate salt, C50H69N15O9, Ac-Nle-Cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, MTII, MelanotanII
PubChemCID 92432

Summary

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis to facilitate tanning.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Melanotan-II reverses memory impairment induced by a short-term HF dietWekwejt P, Wojda U, Kiryk A · Biomed Pharmacother, 2023 · PMID 37478579 · DOI
  2. Melanotan II User Experience: A Qualitative Study of Online Discussion ForumsGilhooley E, Daly S, McKenna D · Dermatology, 2021 · PMID 34464955 · DOI
  3. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR AgonistsResearch Support, Non-U.S. Gov'tTomassi S, Dimmito MP, Cai M et al. · J Med Chem, 2022 · PMID 35188390 · DOI
  4. Melanotan II: a possible cause of renal infarction: review of the literature and case reportCase ReportsReviewPeters B, Hadimeri H, Wahlberg R et al. · CEN Case Rep, 2020 · PMID 31953620 · DOI
  5. Melanotan II injection resulting in systemic toxicity and rhabdomyolysisCase ReportsNelson ME, Bryant SM, Aks SE · Clin Toxicol (Phila), 2012 · PMID 23121206 · DOI
  6. Melanoma associated with the use of melanotan-IIHjuler KF, Lorentzen HF · Dermatology, 2014 · PMID 24355990 · DOI
  7. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized ratGiuliano F, Clément P, Droupy S et al. · Neuroscience, 2006 · PMID 16360286 · DOI
  8. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autismResearch Support, Non-U.S. Gov'tMinakova E, Lang J, Medel-Matus JS et al. · PLoS One, 2019 · PMID 30629642 · DOI

Top 8 of 195 results, by relevance. See all on PubMed.

Search query "Melanotan II"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 92432
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaMelanotan II

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.