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Anti-ageing research

MOTS-c

Peptide encoded in mitochondrial DNA

  • FormulaC101H152N28O22S2
  • Molecular weight2174.6 g/mol
  • CAS number1627580-64-6
  • PubMed results257

Reference sheet 26 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Identification

Field of researchAnti-ageing research
FormulaC101H152N28O22S2
Molecular weight2174.6 g/mol
CAS number1627580-64-6
Also known asMOTS-c (human) (trifluoroacetate salt), A5CV6JFB78, H-MRWQEMGYIFYPRKLR-OH, orb2279120, orb3032863, Mitochondria-derived peptide mots-c, EX-A6267, PP51038, DA-65618, T77782
PubChemCID 146675088

Summary

MOTS-c is a 16-amino-acid peptide that in humans is encoded by the mitochondrial MT-RNR1 gene, with the amino acid sequence MRWQEMGYIFYPRKLR. It is believed to be involved in regulating metabolism of glucose by skeletal muscle tissue.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationReviewResearch Support, Non-U.S. Gov'tZheng Y, Wei Z, Wang T · Front Endocrinol (Lausanne), 2023 · PMID 36761202 · DOI
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tLee C, Zeng J, Drew BG et al. · Cell Metab, 2015 · PMID 25738459 · DOI
  3. Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 DeubiquitinationResearch Support, Non-U.S. Gov'tYin Y, Li Y, Ma B et al. · Adv Sci (Weinh), 2024 · PMID 39321430 · DOI
  4. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReynolds JC, Lai RW, Woodhead JST et al. · Nat Commun, 2021 · PMID 33473109 · DOI
  5. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitusResearch Support, Non-U.S. Gov'tYin Y, Pan Y, He J et al. · Pharmacol Res, 2022 · PMID 34798268 · DOI
  6. MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genesResearch Support, Non-U.S. Gov'tLi X, Zhan F, Qiu G et al. · Redox Biol, 2025 · PMID 40403491 · DOI
  7. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformanceReviewMendias CL, Awan TM · Sports Med, 2026 · PMID 41966639 · DOI
  8. Circulating levels of MOTS-c in patients with breast cancer treated with metforminRandomized Controlled TrialResearch Support, Non-U.S. Gov'tCuyàs E, Verdura S, Martin-Castillo B et al. · Aging (Albany NY), 2022 · PMID 36490309 · DOI

Top 8 of 257 results, by relevance. See all on PubMed.

Search query "MOTS-c"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 146675088
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaMOTS-c

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.