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Skin and hair

Afamelanotide

Chemical compound

  • FormulaC78H111N21O19
  • Molecular weight1646.8 g/mol
  • CAS number75921-69-6
  • PubMed results104

Reference sheet 2 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Sold for in vitro laboratory research only — not for human or animal consumption. ≥99% purity specification.

Identification

Field of researchSkin and hair
FormulaC78H111N21O19
Molecular weight1646.8 g/mol
CAS number75921-69-6
Also known asMelanotan, 4-Norleucyl-7-phenylalanine-alpha-msh, NDPMSH, (Nle(4),D-Phe(7))alpha-MSH, RefChem:57383, D02BB02, 4-Nle-7-Phe-alpha-MSH, afamelanotida, afamelanotidum, alpha-MSH, Nle(4)-Phe(7)-
PubChemCID 16197727

Summary

Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent phototoxicity and to reduce pain from light exposure for people with erythropoietic protoporphyria, a rare form of genetic sun sensitivity.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Vitiligo: Pathogenesis and New and Emerging TreatmentsReviewPerez-Bootello J, Cova-Martin R, Naharro-Rodriguez J et al. · Int J Mol Sci, 2023 · PMID 38139134 · DOI
  2. AfamelanotideReview2012 · PMID 38598652
  3. From pathogenesis of acne vulgaris to anti-acne agentsReviewCong TX, Hao D, Wen X et al. · Arch Dermatol Res, 2019 · PMID 30859308 · DOI
  4. An overview of the cutaneous porphyriasReviewDawe R · F1000Res, 2017 · PMID 29152226 · DOI
  5. Treatment Advances in Vitiligo: An Updated ReviewReviewIsmail IB, Bhat YJ, Ul Islam MS · Dermatol Pract Concept, 2025 · PMID 40117616 · DOI
  6. Phototherapy for VitiligoReviewZubair R, Hamzavi IH · Dermatol Clin, 2020 · PMID 31753192 · DOI
  7. X-Linked ProtoporphyriaReviewAdam MP, Bick S, Mirzaa GM et al. · 1993 · PMID 23409301
  8. Afamelanotide: A Review in Erythropoietic ProtoporphyriaReviewKim ES, Garnock-Jones KP · Am J Clin Dermatol, 2016 · PMID 26979527 · DOI

Top 8 of 104 results, by relevance. See all on PubMed.

Search query "Afamelanotide"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 16197727
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaAfamelanotide

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.