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About / Peptides / Acetyl hexapeptide-8

Skin and hair

Acetyl hexapeptide-8

Chemical compound

  • FormulaC35H62N14O11S
  • Molecular weight887.0 g/mol
  • CAS number616204-22-9
  • PubMed results47

Reference sheet 1 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

Identification

Field of researchSkin and hair
PubChem nameAcetyl hexapeptide-3
FormulaC35H62N14O11S
Molecular weight887.0 g/mol
CAS number616204-22-9
Also known asArgireline NP, Hexapeptide 3, L4EL31FWIL, Acetyl hexapeptide 3, Acetyl-glu-glu-met-gln-arg-arg-amide, RefChem:552452, ACETYL HEXAPEPTIDE-8 [INCI], ACETYL HEXAPEPTIDE-3 [WHO-DD], Argireline, Botulinoid
PubChemCID 71587772

Summary

Acetyl hexapeptide-8, also known as acetyl hexapeptide-8 amide and Argireline, is a synthetic hexapeptide used as a topical cosmetic ingredient that may improve the appearance of wrinkles.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Cosmeceuticals in photoaging: A reviewSystematic ReviewChan LKW, Lee KWA, Lee CH et al. · Skin Res Technol, 2024 · PMID 39233460 · DOI
  2. Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and EfficacyReviewZdrada-Nowak J, Surgiel-Gemza A, Szatkowska M · Int J Mol Sci, 2025 · PMID 40565185 · DOI
  3. A synthetic hexapeptide (Argireline) with antiwrinkle activityBlanes-Mira C, Clemente J, Jodas G et al. · Int J Cosmet Sci, 2002 · PMID 18498523 · DOI
  4. The anti-wrinkle efficacy of ArgirelineWang Y, Wang M, Xiao XS et al. · J Cosmet Laser Ther, 2013 · PMID 23464592 · DOI
  5. Public Interest in Acetyl Hexapeptide-8: Longitudinal AnalysisOlsson SE, Sreepad B, Lee T et al. · JMIR Dermatol, 2024 · PMID 38376906 · DOI
  6. The study of cellular cytotoxicity of argireline - an anti-aging peptideResearch Support, Non-U.S. Gov'tGrosicki M, Latacz G, Szopa A et al. · Acta Biochim Pol, 2014 · PMID 24644551
  7. Argireline: Needle-Free Botox as Analytical ChallengeKluczyk A, Ludwiczak J, Modzel M et al. · Chem Biodivers, 2021 · PMID 33482052 · DOI
  8. The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese SubjectsWang Y, Wang M, Xiao XS et al. · J Cosmet Laser Ther, 2013 · PMID 23607739 · DOI

Top 8 of 47 results, by relevance. See all on PubMed.

Search query "acetyl hexapeptide-3"[Title/Abstract] OR "acetyl hexapeptide-8"[Title/Abstract] OR "argireline"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 71587772
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaAcetyl hexapeptide-8

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.