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Weight research

Semaglutide

Anti-diabetic and anti-obesity medication

  • FormulaC187H291N45O59
  • Molecular weight4114 g/mol
  • CAS number910463-68-2
  • PubMed results5,624

Reference sheet 32 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Identification

Field of researchWeight research
FormulaC187H291N45O59
Molecular weight4114 g/mol
CAS number910463-68-2
Also known asRybelsus, Ozempic, Wegovy, NN9535, NN 9535, NNC 0113-0217, 53AXN4NNHX, NN-9535, CHEBI:167574, NNC-0113-0217
PubChemCID 56843331

Summary

Semaglutide is an anti-diabetic medication used for the treatment of type 2 diabetes, and an anti-obesity medication used for weight management.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trialClinical Trial, Phase IIIRandomized Controlled TrialResearch Support, Non-U.S. Gov'tEquivalence TrialKadowaki T, Isendahl J, Khalid U et al. · Lancet Diabetes Endocrinol, 2022 · PMID 35131037 · DOI
  2. Safety of SemaglutideResearch Support, Non-U.S. Gov'tReviewSmits MM, Van Raalte DH · Front Endocrinol (Lausanne), 2021 · PMID 34305810 · DOI
  3. Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-AnalysisMeta-AnalysisSystematic ReviewTan HC, Dampil OA, Marquez MM · J ASEAN Fed Endocr Soc, 2022 · PMID 36578889 · DOI
  4. A systematic review of the effect of semaglutide on lean mass: insights from clinical trialsSystematic ReviewBikou A, Dermiki-Gkana F, Penteris M et al. · Expert Opin Pharmacother, 2024 · PMID 38629387 · DOI
  5. Semaglutide lowers body weight in rodents via distributed neural pathwaysResearch Support, Non-U.S. Gov'tGabery S, Salinas CG, Paulsen SJ et al. · JCI Insight, 2020 · PMID 32213703 · DOI
  6. Wegovy (semaglutide): a new weight loss drug for chronic weight managementReviewSingh G, Krauthamer M, Bjalme-Evans M · J Investig Med, 2022 · PMID 34706925 · DOI
  7. Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection FractionComparative StudyObservational StudyKrüger N, Schneeweiss S, Fuse K et al. · JAMA, 2025 · PMID 40886075 · DOI
  8. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trialRandomized Controlled TrialMulticenter StudyResearch Support, Non-U.S. Gov'tRyan DH, Lingvay I, Deanfield J et al. · Nat Med, 2024 · PMID 38740993 · DOI

Top 8 of 5,624 results, by relevance. See all on PubMed.

Search query "Semaglutide"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 56843331
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaSemaglutide

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.