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Retatrutide

Chemical compound

  • FormulaC221H342N46O68
  • Molecular weight4731 g/mol
  • PubMed results193

Reference sheet 30 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Sold for in vitro laboratory research only — not for human or animal consumption. ≥99% purity specification.

Identification

Field of researchWeight research
PubChem nameTriple G
FormulaC221H342N46O68
Molecular weight4731 g/mol
Also known asorb1981169, EX-A7826E, GTPL13769, T76279
PubChemCID 171390338

Summary

Retatrutide is an experimental drug for obesity developed by the American pharmaceutical company Eli Lilly and Company.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trialRandomized Controlled TrialClinical Trial, Phase IIIMulticenter StudyResearch Support, Non-U.S. Gov'tBajaj HS, Welch M, Shah P et al. · Lancet, 2026 · PMID 42250575 · DOI
  2. Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled TrialsSystematic ReviewMoiz A, Filion KB, Toutounchi H et al. · Ann Intern Med, 2025 · PMID 39761578 · DOI
  3. Novel GLP-1-based Medications for Type 2 Diabetes and ObesityReviewSon JW, le Roux CW, Blüher M et al. · Endocr Rev, 2026 · PMID 41054801 · DOI
  4. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 TrialRandomized Controlled TrialClinical Trial, Phase IIJastreboff AM, Kaplan LM, Frías JP et al. · N Engl J Med, 2023 · PMID 37366315 · DOI
  5. Retatrutide-A Game Changer in Obesity PharmacotherapyReviewKatsi V, Koutsopoulos G, Fragoulis C et al. · Biomolecules, 2025 · PMID 40563436 · DOI
  6. Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and ObesityReviewResearch Support, Non-U.S. Gov'tDrucker DJ · Diabetes Care, 2024 · PMID 38843460 · DOI
  7. Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db miceComparative StudyMa J, Hu X, Zhang W et al. · Endocrine, 2025 · PMID 39212900 · DOI
  8. Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic review and network meta-analysisComparative StudyNetwork Meta-AnalysisSystematic ReviewLiu S, Hu J, Zhao C et al. · Front Endocrinol (Lausanne), 2025 · PMID 39968298 · DOI

Top 8 of 193 results, by relevance. See all on PubMed.

Search query "Retatrutide"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 171390338
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaRetatrutide

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.