Palmitoyl pentapeptide-4

Chemical compound

FormulaC₃₉H₇₅N₇O₁₀
Molecular weight802.1 g/mol
CAS number214047-00-4
PubMed results20

Reference sheet 29 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

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Identification

Field of research	Skin and hair
Formula	C₃₉H₇₅N₇O₁₀
Molecular weight	802.1 g/mol
CAS number	214047-00-4
Also known as	Palmitoyl pentapeptide-3, Oristar popp, Lipopentapeptide 3, PAL-Lys-Thr-Thr-Lys-Ser, Palmitoyl pentapeptide-4 [INCI], RefChem:858432, Matrixyl, Pal-KTTKS, Pal-Lys-Thr-Thr-Lys-Ser-OH, Palmitoyl pentapeptide 4
PubChem	CID 9897237

Summary

Palmitoyl pentapeptide-4 is a matrikine used in anti-wrinkle cosmetics.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinRobinson LR, Fitzgerald NC, Doughty DG et al. · Int J Cosmet Sci, 2005 · PMID 18492182 · DOI
Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal PeptidesWang Z, Liu J, Chen Q et al. · Adv Sci (Weinh), 2025 · PMID 39783908 · DOI
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS)Choi YL, Park EJ, Kim E et al. · Biomol Ther (Seoul), 2014 · PMID 25143811 · DOI
The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic ActivityTałałaj U, Uścinowicz P, Bruzgo I et al. · Molecules, 2019 · PMID 31618846 · DOI
Liposome Encapsulation of the Palmitoyl-KTTKS Peptide: Structural and Functional CharacterizationVitali A, Paolicelli P, Bigi B et al. · Pharmaceutics, 2024 · PMID 38399273 · DOI
Mesenchymal stem cell therapy using Pal-KTTKS-enriched carboxylated cellulose improves burn wound in rat modelRasouli M, Shahghasempour L, Shirbaghaee Z et al. · Arch Dermatol Res, 2024 · PMID 38850353 · DOI
Effect of Palmitic Acid Conjugation on Physicochemical Properties of Peptide KTTKS: A Preformulation StudyMortazavi SM, Kobarfard F, Maibach HI et al. · J Cosmet Sci, 2019 · PMID 31829923
Practical application of cellular bioenergetics to the care of aged skinResearch Support, Non-U.S. Gov'tOsborne R, Carver RS, Mullins LA et al. · Br J Dermatol, 2013 · PMID 23786618 · DOI

Top 8 of 20 results, by relevance. See all on PubMed.

Search query "palmitoyl pentapeptide-4"[Title/Abstract] OR "pal-KTTKS"[Title/Abstract] OR "palmitoyl pentapeptide"[Title/Abstract]

Data provenance

Data	Source	Record
Chemical identity and structure	PubChem	CID 9897237
Published literature	PubMed	Search on PubMed
Summary sentence	Wikipedia	Palmitoyl pentapeptide-4

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.