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Focus and sleep

Dihexa

Chemical compound

  • FormulaC27H44N4O5
  • Molecular weight504.7 g/mol
  • CAS number1401708-83-5
  • PubMed results18

Reference sheet 9 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

Identification

Field of researchFocus and sleep
PubChem nameN-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
FormulaC27H44N4O5
Molecular weight504.7 g/mol
CAS number1401708-83-5
Also known as9WYX65A5C2, PNB-0408, ATH-1001, RefChem:1090816, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, Hexanoyl-Tyr-Ile-Ahx-NH2, C27H44N4O5, Dihexa (PNB-0408)?, orb1220467, orb1685499
PubChemCID 129010512

Summary

Dihexa is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsReviewRahman OF, Lee SJ, Seeds WA · J Am Acad Orthop Surg Glob Res Rev, 2026 · PMID 41490200 · DOI
  2. Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposureUribe PM, Kawas LH, Harding JW et al. · Front Cell Neurosci, 2015 · PMID 25674052 · DOI
  3. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met systemResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tRetracted PublicationBenoist CC, Kawas LH, Zhu M et al. · J Pharmacol Exp Ther, 2014 · PMID 25187433 · DOI
  4. AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling PathwaySun X, Deng Y, Fu X et al. · Brain Sci, 2021 · PMID 34827486 · DOI
  5. The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's DiseaseResearch Support, Non-U.S. Gov'tReviewWright JW, Harding JW · J Alzheimers Dis, 2015 · PMID 25649658 · DOI
  6. Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activityResearch Support, Non-U.S. Gov'tBapst JP, Froidevaux S, Calame M et al. · J Recept Signal Transduct Res, 2007 · PMID 18097939 · DOI
  7. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agentsResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tMcCoy AT, Benoist CC, Wright JW et al. · J Pharmacol Exp Ther, 2013 · PMID 23055539 · DOI
  8. Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studiesWeiss JB, Phillips CJ, Malin EW et al. · Ann Med Surg (Lond), 2021 · PMID 34703584 · DOI

Top 8 of 18 results, by relevance. See all on PubMed.

Search query "Dihexa"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 129010512
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaDihexa

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.