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Anti-ageing research

Humanin

Micropeptide encoded by mitochondrial DNA

  • FormulaC119H204N34O32S2
  • Molecular weight2687.2 g/mol
  • CAS number330936-69-1
  • PubMed results547

Reference sheet 18 of 40Data retrieved 2026-10-08.PubChem · PubMed · Wikipedia

Identification

Field of researchAnti-ageing research
FormulaC119H204N34O32S2
Molecular weight2687.2 g/mol
CAS number330936-69-1
Also known asH975EUX36G, RefChem:146895, HUMANIN TRIFLUOROACETATE, formyl humanin, Protein Humanin (human), Humanin, human, 1-24-Protein humanin (human), Protein (human clone 1 humanin sequence homolog), 1-24-Protein humanin, GTPL1047
PubChemCID 16131438

Summary

Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2.

From Wikipedia, available under CC BY-SA 4.0. Short description from Wikidata (CC0).

Published research

Titles are shown as published. Listing a paper is not an endorsement of its findings, and many papers on research peptides are laboratory or animal studies: the type of study is shown when PubMed records it.

  1. Mitochondrial stress and mitokines in agingReviewResearch Support, Non-U.S. Gov'tBurtscher J, Soltany A, Visavadiya NP et al. · Aging Cell, 2023 · PMID 36642986 · DOI
  2. Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's diseaseRandomized Controlled TrialResearch Support, N.I.H., IntramuralResearch Support, Non-U.S. Gov'tDelgado-Peraza F, Nogueras-Ortiz C, Simonsen AH et al. · Alzheimers Res Ther, 2023 · PMID 37730689 · DOI
  3. Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signalingResearch Support, Non-U.S. Gov'tCheng J, Li M, Motta E et al. · Cell Rep Med, 2024 · PMID 39053460 · DOI
  4. Humanin: Functional Interfaces with IGF-IReviewResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tXiao J, Kim SJ, Cohen P et al. · Growth Horm IGF Res, 2016 · PMID 27082450 · DOI
  5. Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neuronsResearch Support, Non-U.S. Gov'tKim SK, Tran LT, NamKoong C et al. · Nat Commun, 2023 · PMID 37468558 · DOI
  6. Humanin and the receptors for humaninResearch Support, Non-U.S. Gov'tReviewMatsuoka M, Hashimoto Y · Mol Neurobiol, 2010 · PMID 19997871 · DOI
  7. Mitochondrial-Derived Peptides Exacerbate SenescenceReviewMendelsohn AR, Larrick JW · Rejuvenation Res, 2018 · PMID 30058454 · DOI
  8. The role of humanin in the regulation of reproductionResearch Support, Non-U.S. Gov'tReviewLei H, Rao M · Biochim Biophys Acta Gen Subj, 2022 · PMID 34626748 · DOI

Top 8 of 547 results, by relevance. See all on PubMed.

Search query "Humanin"[Title/Abstract]

Data provenance

DataSourceRecord
Chemical identity and structurePubChemCID 16131438
Published literaturePubMedSearch on PubMed
Summary sentenceWikipediaHumanin

Data retrieved 2026-10-08. See About for the sources. How the data is collected and checked: Methods.